RESUMO
PURPOSE: To assess the systemic response of pigs to the intraperitoneal implantation of polypropylene mesh associated with chitosan-based film with a degree of deacetylation of 95%. METHODS: Blood samples were collected 24 hours before, and two and seven days after surgery. Systemic reactions were evaluated based on white blood cell count, C-reactive protein, and total serum protein, albumin and globulin levels. RESULTS: The systemic response was proportional to the composite response induced by polypropylene mesh, and the tissue inflammatory response was higher in the PP group (p=0.0033). CONCLUSION: The polypropylene mesh/chitosan-based film composite did not elicit a systemic response in pigs.
Assuntos
Parede Abdominal/cirurgia , Reação de Fase Aguda/etiologia , Quitosana/uso terapêutico , Materiais Revestidos Biocompatíveis/uso terapêutico , Polipropilenos/uso terapêutico , Telas Cirúrgicas , Animais , Proteína C-Reativa/análise , Contagem de Leucócitos , Masculino , Teste de Materiais , Cavidade Peritoneal/cirurgia , Distribuição Aleatória , Reprodutibilidade dos Testes , Albumina Sérica/análise , Soroglobulinas/análise , Suínos , Fatores de TempoRESUMO
PURPOSE:To assess the systemic response of pigs to the intraperitoneal implantation of polypropylene mesh associated with chitosan-based film with a degree of deacetylation of 95%.METHODS:Blood samples were collected 24 hours before, and two and seven days after surgery. Systemic reactions were evaluated based on white blood cell count, C-reactive protein, and total serum protein, albumin and globulin levels.RESULTS:The systemic response was proportional to the composite response induced by polypropylene mesh, and the tissue inflammatory response was higher in the PP group (p=0.0033).CONCLUSION:The polypropylene mesh/chitosan-based film composite did not elicit a systemic response in pigs.
